PRKAR2A

PRKAR2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IZX, 2KYG, 4ZP3
Identifiers
Aliases	PRKAR2A, PKR2, PRKAR2, protein kinase cAMP-dependent type II regulatory subunit alpha
External IDs	MGI: 108025 HomoloGene: 3064 GeneCards: PRKAR2A
Gene ontology Molecular function • nucleotide binding • protein kinase A catalytic subunit binding • cAMP binding • protein binding • cAMP-dependent protein kinase regulator activity • cAMP-dependent protein kinase inhibitor activity • ubiquitin protein ligase binding Cellular component • cytoplasm • cytosol • centrosome • membrane • focal adhesion • plasma membrane raft • plasma membrane • ciliary base • nucleotide-activated protein kinase complex • cAMP-dependent protein kinase complex • extracellular exosome Biological process • regulation of protein phosphorylation • activation of protein kinase A activity • intracellular signal transduction • cellular response to glucagon stimulus • blood coagulation • negative regulation of cAMP-dependent protein kinase activity • renal water homeostasis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5576	19087
Ensembl	ENSG00000114302	ENSMUSG00000032601
UniProt	P13861	P12367
RefSeq (mRNA)	NM_004157 NM_001321982 NM_001321983 NM_001321989	NM_008924
RefSeq (protein)	NP_001308911 NP_001308912 NP_001308918 NP_004148	n/a
Location (UCSC)	Chr 3: 48.74 – 48.85 Mb	Chr 9: 108.69 – 108.75 Mb
PubMed search

2IZX, 2KYG, 4ZP3

5576

19087

ENSG00000114302

ENSMUSG00000032601

P13861

P12367

NM_004157
NM_001321982
NM_001321983
NM_001321989

NM_008924

NP_001308911
NP_001308912
NP_001308918
NP_004148

n/a

cAMP-dependent protein kinase type II-alpha regulatory subunit is an enzyme that in humans is encoded by the PRKAR2A gene.

cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent Protein Kinase, more commonly called Protein Kinase A (PKA), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of PKA is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of PKA have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins (AKAPs) and determine the subcellular localization of PKA. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER).

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