5-HT5A

HTR5A
Identifiers
Aliases	HTR5A, 5-HT5A, 5-HT5A receptor, 5-hydroxytryptamine receptor 5A
External IDs	MGI: 96283 HomoloGene: 22461 GeneCards: HTR5A
Targeted by Drug
5-carboxamidotryptamine, pathogen, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, donitriptan, EMDT, ru-24969, sumatriptan, clozapine, ergotamine, ketanserin, metergoline, metitepine, methysergide, ritanserin, vortioxetine, yohimbine, SB 699551
Gene ontology Molecular function • G-protein coupled receptor activity • signal transducer activity • G-protein coupled serotonin receptor activity • neurotransmitter receptor activity • serotonin binding Cellular component • integral component of membrane • perikaryon • plasma membrane • rough endoplasmic reticulum • Golgi apparatus • integral component of plasma membrane • membrane • dendrite Biological process • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • brain development • response to estradiol • hippocampus development • cAMP-mediated signaling • signal transduction • adenylate cyclase-inhibiting serotonin receptor signaling pathway • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3361	15563
Ensembl	ENSG00000157219	ENSMUSG00000039106
UniProt	P47898	P30966
RefSeq (mRNA)	NM_024012	NM_008314
RefSeq (protein)	NP_076917	NP_032340.2
Location (UCSC)	Chr 7: 155.07 – 155.09 Mb	Chr 5: 27.84 – 27.86 Mb
PubMed search

3361

15563

ENSG00000157219

ENSMUSG00000039106

P47898

P30966

NM_024012

NM_008314

NP_076917

NP_032340.2

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.

The gene described in this record is a member of 5-hydroxytryptamine receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G proteins, negatively influencing cAMP levels via G_i and G_o. This protein has been shown to function in part through the regulation of intracellular Ca²⁺ mobilization. The 5-HT_5A receptor has been shown to be functional in a native expression system.

Rodents have been shown to possess two functional 5-HT₅ receptor subtypes, 5-HT_5A and 5-HT_5B, however while humans possess a gene coding for the 5-HT_5B subtype, its coding sequence is interrupted by stop codons, making the gene non-functional, and so only the 5-HT_5A subtype is expressed in human brain.

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