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5-HT5A

HTR5A
Identifiers
Aliases HTR5A, 5-HT5A, 5-HT5A receptor, 5-hydroxytryptamine receptor 5A
External IDs MGI: 96283 HomoloGene: 22461 GeneCards: HTR5A
Targeted by Drug
5-carboxamidotryptamine, pathogen, (+/-)-8-hydroxy-2-(di-N-propylamino)tetralin, donitriptan, EMDT, ru-24969, sumatriptan, clozapine, ergotamine, ketanserin, metergoline, metitepine, methysergide, ritanserin, vortioxetine, yohimbine, SB 699551
RNA expression pattern
PBB GE HTR5A 221362 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_024012

NM_008314

RefSeq (protein)

NP_076917

NP_032340.2

Location (UCSC) Chr 7: 155.07 – 155.09 Mb Chr 5: 27.84 – 27.86 Mb
PubMed search

NM_024012

NM_008314

NP_076917

NP_032340.2

5-Hydroxytryptamine (serotonin) receptor 5A, also known as HTR5A, is a protein that in humans is encoded by the HTR5A gene.

The gene described in this record is a member of 5-hydroxytryptamine receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G proteins, negatively influencing cAMP levels via Gi and Go. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. The 5-HT5A receptor has been shown to be functional in a native expression system.

Rodents have been shown to possess two functional 5-HT5 receptor subtypes, 5-HT5A and 5-HT5B, however while humans possess a gene coding for the 5-HT5B subtype, its coding sequence is interrupted by stop codons, making the gene non-functional, and so only the 5-HT5A subtype is expressed in human brain.


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Wikipedia

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