The 1983 Major League Baseball All-Star Game was the 50th playing of the midsummer classic between the all-stars of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on Wednesday, July 6, 1983, at Comiskey Park in Chicago, Illinois, the home of the Chicago White Sox of the American League. The game resulted in the American League defeating the National League 13-3. The game occurred exactly 50 years to the date of the first All-Star game.

This was the fifth All-Star Game to be played in Chicago, and the third to be hosted by the White Sox at Comiskey Park (the other two being hosted by the Chicago Cubs at Wrigley Field). This would be the last time that the All-Star Game would be hosted in the stadium where the annual exhibition began. When the White Sox next hosted the All-Star Game in 2003, they had moved across the street to their new home at U.S. Cellular Field.

The game was the first American League win since 1971, and only their second win since 1963. The 13 runs scored by the American League set a new record for one team in All-Star Game history. The ten-run margin of victory was the largest since the 12-0 American League victory in 1946.

The game is perhaps best remembered for Fred Lynn's third inning grand slam. As of the 2016 All Star Game, it is still the only grand slam in the history of the Midsummer Classic.

Prior to the start of the game, Chuck Mangione played the Canadian National Anthem, while the Oak Ridge Boys sang the United States National Anthem. The colors presentation was by the Great Lakes Naval Training Center Color Guard, which previously presented the colors at the 1947, 1950 and 1963 All-Star Games and would do the honors again in 1990 and 2003.

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