The 1950 Major League Baseball All-Star Game was the 17th playing of the midsummer classic between the all-stars of the American League (AL) and National League (NL), the two leagues comprising Major League Baseball. The game was held on July 11, 1950, at Comiskey Park in Chicago the home of the Chicago White Sox of the American League. The game resulted in the National League defeating the American League 4–3 in 14 innings. It was the first All-Star game to go into extra innings.

The White Sox hosted the game and were represented by pitcher Ray Scarborough, who did not appear in the game.

Players in italics have since been inducted into the National Baseball Hall of Fame.

The umpires changed assignments in the middle of the fifth inning – Pinelli to home, Rommel to first, Conlan to second, and McGowan to third.

Vic Raschi and Robin Roberts were the starting pitchers for the AL and NL, respectively.

The NL scored first in the top of the 2nd inning, pushing across 2 runs on a single by Jackie Robinson followed by a triple by Enos Slaughter, who then scored on a flyout by Hank Sauer. The AL got 1 run back in the bottom of the 3rd inning, when Cass Michaels scored from third base on a flyout by George Kell. The AL then pulled ahead 3–2 in the bottom of the 5th inning; with runners on second and third with one out, Bob Lemon scored from third base on a flyout by George Kell, and Larry Doby then scored on a single by Ted Williams.

There was no further scoring until the top of the 9th inning, when the NL's Ralph Kiner hit a home run off of AL reliever Art Houtteman, tying the score 3–3. The NL benefitted from five innings of scoreless relief from Larry Jansen, who faced 16 batters striking out 6, while allowing just one hit.

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