The 2003 Major League Baseball All-Star Game was the 74th midsummer classic between the all-stars of the American League (AL) and National League (NL), the two leagues constituting Major League Baseball, and celebrated the 70th anniversary of the inaugural All-Star Game played in Chicago, Illinois in 1933.

The game was held on July 15, 2003 at U.S. Cellular Field, the home of the Chicago White Sox of the American League. The game resulted in the American League defeating the National League 7–6, thus awarding an AL team (which was eventually the New York Yankees) home-field advantage in the 2003 World Series. This game was the first All-Star Game to award home-field advantage in the World Series to the winning league, a rule that stemmed from a controversial 7–7 tie in the previous year's edition. In the days leading up to the game, Fox advertised it with the tagline: "This time it counts." Subsequent editions altered the slogan to "This one counts" to reflect the new method of determining the World Series' home-field advantage.

This All-Star Game marked the seventh All-Star appearance for the Naval Station Great Lakes color guard from Waukegan, Illinois, who this year was joined by police officers from the Kane County Sheriff's Department who presented the Canadian and American flags in the outfield. Both the five-man color guard and the sheriff's department officers accompanied Michael Bublé, who sang O Canada, and Vanessa Carlton, who sang The Star-Spangled Banner. Bublé's performance of "O Canada" was not televised until after the game in the Chicago area, while Carlton's performance was followed by fireworks that shot off the U.S. Cellular Field scoreboard.

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