The 2003 World Series was the 99th edition of Major League Baseball's championship series. The Florida Marlins of the National League defeated the heavily favored New York Yankees of the American League in six games with a score of 4–2. This is the most recent Series in which the losing team outscored the winning team. The Yankees lost, despite outscoring the Marlins 21–17 in the Series. This was the Marlins' second World Series championship win and their first since 1997.

The 2003 World Series featured the New York Yankees in their sixth Series appearance in eight years. Opposing them were the wild card Florida Marlins, appearing in their second World Series in their eleven-year franchise history. The Marlins became the second straight wild card team to win the World Series; the Anaheim Angels won in 2002. The series was, however, somewhat overshadowed by the League Championship Series that year, when the Chicago Cubs and the Boston Red Sox, both widely believed to be cursed, went down in dramatic defeats only five outs away from the pennant, and each in seven games. However, Marlins manager Jack McKeon disagreed, and having lived in South Amboy, New Jersey and attending Yankee games when a child, said that he wanted to play the Yankees in his first World Series.

By losing the series, the Yankees became the first team to lose two World Series to post 1960 expansion teams; losing to the Arizona Diamondbacks, who entered the National League in 1998, in the 2001 World Series and now the Marlins who entered the National League in 1993.

It was the 100th anniversary of the World Series, and advertised as such. However, it was only the 99th event due to a strike cancelling the 1994 World Series and the boycott of the 1904 World Series by the National League.

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