*** Welcome to piglix ***

Voriconazole

Voriconazole
Voriconazole structure.svg
Voriconazole ball-and-stick model.png
Clinical data
Pronunciation vor-i-KON-a-zole
Trade names Vfend
AHFS/Drugs.com Monograph
MedlinePlus a605022
License data
Pregnancy
category
  • D
Routes of
administration
IV, by mouth (tablets, oral suspension)
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability 96% (oral administration)
Protein binding 58%
Metabolism Liver: CYP2C19 (significant involvement), also CYP2C9, CYP3A4
Metabolites Voriconazole N-oxide (major; minimal antifungal activity)
Biological half-life Dose-dependent
Excretion Urine (80–83%)
Identifiers
Synonyms RS)-α-(2,4-Difluorophenyl)-5-fluoro-β-methyl-α-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
Formula C16H14F3N5O
Molar mass 349.311 g/mol
3D model (Jmol)
  

Voriconazole (INN, brand name Vfend VEE-fend, manufactured by Pfizer) is a triazole antifungal medication that is generally used to treat serious, invasive fungal infections. These are generally seen in patients who are immunocompromised, and include invasive candidiasis, invasive aspergillosis, and certain emerging fungal infections.

Voriconazole is used to treat invasive aspergillosis, which may occur in immunocompromised patients, including allogeneic BMT, hematologic cancers, and solid organ transplants.

For multiple site or CNS aspergillosis a combination therapy of voriconazole and liposomal amphotericin B should be considered. It is also the recommended treatment for the CNS fungal infections transmitted by epidural injection of contaminated steroids.

Voriconazole has proven to be as effective as a regimen of intravenous amphotericin B followed by oral fluconazole in patients with culture-proven candidemia. Voriconazole cleared Candida from the bloodstream as quickly as amphotericin B (median 2 days) and showed a trend toward better survival. Voriconazole was also associated with fewer serious adverse events and cases of renal toxicity, but a higher incidence of visual disturbances.


...
Wikipedia

...