US 601
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| Route information | |||||||||
| Auxiliary route of US 1 | |||||||||
| Length: | 316.3 mi (509.0 km) | ||||||||
| Existed: | 1927 – present | ||||||||
| Major junctions | |||||||||
| South end: |
 US 321 near Tarboro, SC
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 US 78 in Bamberg, SC I-26 near Orangeburg, SC I-20 near Lugoff, SC US 1 in Camden, SC US 74 in Monroe, NC I‑85 near Salisbury, NC I‑40 near Mocksville, NC US 421 near Yadkinville, NC I‑74 near Mount Airy, NC
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| North end: |
 US 52 in Mount Airy, NC
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| Location | |||||||||
| States: | South Carolina, North Carolina | ||||||||
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U.S. Route 601 (US 601) is a north–south United States highway that runs for 316.3 miles (509.0 km) from U.S. Route 321, near Tarboro, South Carolina, to U.S. Route 52, in Mount Airy, North Carolina.
US 601 begins at US 321 near Tarboro, SC and intersects with such highways as US 278 in Hampton, US 301 between Bamberg and Orangeburg, US 78 in Bamberg, Interstate 26 near Orangeburg Interstate 20 near Lugoff, US 1 in Camden, US 521 between Camden and Kershaw, and SC 9 in Pageland.
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