U.S. Route 521 in North Carolina
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| Length: | 177.3 mi (285.3 km) | ||||||||
| Existed: | 1932 – present | ||||||||
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| South end: |
 US 17 in Georgetown, SC
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 US 17 Alt. in Georgetown, SC I-95 near Manning, SC  US 15 / US 401 in Sumter, SC     US 76 / US 76 Bus. / US 378 in Sumter, SC I-20 in Camden, SC   US 1 / US 601 / SC 34 in Camden, SC
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| North end: |
 I‑485 in Charlotte, NC
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| States: | South Carolina, North Carolina | ||||||||
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U.S. Route 521 is a north–south United States highway that traverses 177.3 miles (285.3 km), from Georgetown, South Carolina to Charlotte, North Carolina. Though numbered as a daughter route of U.S. Route 21, it does not actually intersect its parent or any of its sibling routes, though it is in the same general part of the U.S. as other routes from its family. Historically, it once connected to U.S. 21 in Pineville, North Carolina, but various changes have left it terminating a few miles short of the current U.S. 21.
Starting at the city of Georgetown, US 521 runs through the town Andrews to Greeleyville. From here to the city of Manning it is known as the Greeleyville Highway. There is a brief section right before Manning where it runs concurrent with SC 261. In Manning SC 261 branches off and US 521 merges with US 301 for a short distance. It crosses of Interstate 95 and heads to the city of Sumter, South Carolina. In Sumter, it runs together with US Business 378. Leaving Sumter, US 521 is known as Camden Highway. It passes under Interstate 20 and proceeds to Camden. It then goes on to the town of Kershaw, running concurrent with US 601. The final city it goes through before going into North Carolina is Lancaster.
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