Testis-determining factor

SRY
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1HRY, 1HRZ, 1J46, 1J47, 2GZK
Identifiers
Aliases	SRY, SRXX1, SRXY1, TDF, TDY, Testis determining factor, sex determining region Y, Sex-determining region of Y-chromosome, Sex-determining region Y
External IDs	OMIM: 480000 HomoloGene: 48168 GeneCards: SRY
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • transcription factor binding • calmodulin binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • DNA binding Cellular component • cytoplasm • nuclear speck • nucleoplasm • nucleus Biological process • cell differentiation • regulation of transcription, DNA-templated • sex differentiation • GO:0006350 transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of male gonad development • male sex determination • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6736	n/a
Ensembl	ENSG00000184895	n/a
UniProt	Q05066	n/a
RefSeq (mRNA)	NM_003140	n/a
RefSeq (protein)	NP_003131	n/a
Location (UCSC)	Chr Y: 2.79 – 2.79 Mb	n/a
PubMed search		n/a

1HRY, 1HRZ, 1J46, 1J47, 2GZK

6736

n/a

ENSG00000184895

n/a

Q05066

n/a

NM_003140

n/a

NP_003131

n/a

Testis-determining factor (TDF), also known as sex-determining region Y (SRY) protein, is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination in humans. SRY is an intronless sex-determining gene on the Y chromosome in therians (placental mammals and marsupials); mutations in this gene lead to a range of sex-related disorders with varying effects on an individual's phenotype and genotype.

TDF is a member of the SOX (SRY-like box) gene family of DNA-binding proteins. When complexed with the SF1 protein, TDF acts as a transcription factor that can upregulate other transcription factors, most importantly SOX9. Its expression causes the development of primary sex cords, which later develop into seminiferous tubules. These cords form in the central part of the yet-undifferentiated gonad, turning it into a testis. The now-induced Leydig cells of the testis then start secreting testosterone, while the Sertoli cells produce anti-Müllerian hormone. SRY gene effects normally take place 6–8 weeks after foetus formation and inhibits the female anatomical structural growth in males. It also works towards developing the dominant male characteristics.

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