TRPV1

TRPV1
Identifiers
Aliases	TRPV1, VR1, transient receptor potential cation channel subfamily V member 1
External IDs	OMIM: 602076 MGI: 1341787 HomoloGene: 12920 GeneCards: TRPV1
Targeted by Drug
anandamide, capsaicin, piperine, 5S-HETE, camphor, Hydron, capsazepine, 2-aminoethoxydiphenylborate, 5'-iodoresiniferatoxin, allicin, NADA, anandamide, capsaicin, piperine, 5S-HETE, camphor, Hydron, capsazepine, 2-aminoethoxydiphenylborate, 5'-iodoresiniferatoxin, allicin, NADA
Gene ontology Molecular function • nucleotide binding • calmodulin binding • ion channel activity • phosphoprotein binding • ATP binding • cation transmembrane transporter activity • cation channel activity • ligand-gated ion channel activity • calcium-release channel activity • temperature-gated ion channel activity • identical protein binding • chloride channel regulator activity • transmembrane signaling receptor activity • excitatory extracellular ligand-gated ion channel activity • calcium channel activity • extracellular ligand-gated ion channel activity • phosphatidylinositol binding • metal ion binding Cellular component • integral component of membrane • postsynaptic membrane • cell projection • membrane • plasma membrane • synapse • cell junction • dendritic spine membrane • cytosol • neuronal cell body • intrinsic component of plasma membrane • dendrite • external side of plasma membrane • neuron projection • integral component of plasma membrane Biological process • ion transport • chemosensory behavior • cell surface receptor signaling pathway • calcium ion transmembrane transport • transport • thermoception • calcium ion transport • inflammatory response • transmembrane transport • release of sequestered calcium ion into cytosol • negative regulation of transcription from RNA polymerase II promoter • diet induced thermogenesis • detection of chemical stimulus involved in sensory perception of pain • microglial cell activation • cellular response to growth factor stimulus • positive regulation of gastric acid secretion • response to peptide hormone • cellular response to nerve growth factor stimulus • positive regulation of nitric oxide biosynthetic process • negative regulation of establishment of blood-brain barrier • lipid metabolic process • temperature homeostasis • response to heat • cellular response to temperature stimulus • positive regulation of cytosolic calcium ion concentration • peptide secretion • detection of temperature stimulus involved in sensory perception of pain • sensory perception of mechanical stimulus • smooth muscle contraction involved in micturition • behavioral response to pain • response to pain • cellular response to alkaloid • cellular response to cytokine stimulus • fever generation • detection of temperature stimulus involved in thermoception • positive regulation of apoptotic process • urinary bladder smooth muscle contraction • glutamate secretion • sensory perception of pain • cellular response to tumor necrosis factor • cellular response to ATP • ion transmembrane transport • response to pH • response to organonitrogen compound • cellular response to heat • protein homotetramerization • excitatory postsynaptic potential • cellular response to acidic pH • response to capsazepine • calcium ion import into cell Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7442	193034
Ensembl	ENSG00000196689	ENSMUSG00000005952
UniProt	Q8NER1	Q704Y3
RefSeq (mRNA)	NM_018727 NM_080704 NM_080705 NM_080706	NM_001001445
RefSeq (protein)	NP_061197 NP_542435 NP_542436 NP_542437 NP_061197 NP_542435 NP_542436 NP_542437	NP_001001445.1 NP_001001445
Location (UCSC)	Chr 17: 3.57 – 3.61 Mb	Chr 11: 73.23 – 73.26 Mb
PubMed search

7442

193034

ENSG00000196689

ENSMUSG00000005952

Q8NER1

Q704Y3

NM_018727
NM_080704
NM_080705
NM_080706

NM_001001445

NP_542435
NP_542436
NP_542437

NP_001001445.1
NP_001001445

The transient receptor potential cation channel subfamily V member 1 (TrpV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein that, in humans, is encoded by the TRPV1 gene. It was the first isolated member of the transient receptor potential vanilloid receptor proteins that in turn are a sub-family of the transient receptor potential protein group. This protein is a member of the TRPV group of transient receptor potential family of ion channels.

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