TRPC3

TRPC3
Identifiers
Aliases	TRPC3, SCA41, TRP3, transient receptor potential cation channel subfamily C member 3
External IDs	MGI: 109526 HomoloGene: 20708 GeneCards: TRPC3
Gene location (Human) Chr. Chromosome 4 (human) Band 4q27 Start 121,879,027 bp End 121,951,754 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 B|3 17.93 cM Start 36,620,482 bp End 36,690,167 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • store-operated calcium channel activity • calcium channel activity • inositol 1,4,5 trisphosphate binding • ion channel activity • protein binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • response to ATP • positive regulation of calcium ion transport into cytosol • ion transport • single fertilization • platelet activation • response to calcium ion • calcium ion transmembrane transport • positive regulation of cardiac muscle hypertrophy in response to stress • manganese ion transport • calcium ion transport • phototransduction • transmembrane transport • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7222	22065
Ensembl	ENSG00000138741	ENSMUSG00000027716
UniProt	Q13507	Q9QZC1
RefSeq (mRNA)	NM_001130698 NM_003305	NM_019510
RefSeq (protein)	NP_001124170 NP_003296	n/a
Location (UCSC)	Chr 4: 121.88 – 121.95 Mb	Chr 4: 36.62 – 36.69 Mb
PubMed search

7222

22065

ENSG00000138741

ENSMUSG00000027716

Q13507

Q9QZC1

NM_001130698
NM_003305

NM_019510

NP_001124170
NP_003296

n/a

Short transient receptor potential channel 3 (TrpC3) also known as transient receptor protein 3 (TRP-3) is a protein that in humans is encoded by the TRPC3 gene. The TRPC3/6/7 subfamily are implicated in the regulation of vascular tone, cell growth, proliferation and pathological hypertrophy. These are diacylgylcerol-sensitive cation channels known regulate intracellular calcium via activation of the phospholipase C (PLC) pathway and/or by sensing Ca2+ store depletion. Together, their role in calcium homeostasis has made them potential therapeutic targets for a variety of central and peripheral pathologies.

Non-specific cation conductance elicited by the activation of TrkB by BDNF is TRPC3-dependent in the CNS. TRPC channels are almost always co-localized with mGluR1-expressing cells and likely play a role in mGluR-mediated EPSPs.

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Wikipedia