Metabotropic glutamate receptor 1

GRM1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3KS9, 4OR2
Identifiers
Aliases	GRM1, GPRC1A, MGLU1, MGLUR1, PPP1R85, SCAR13, glutamate metabotropic receptor 1
External IDs	MGI: 1351338 HomoloGene: 649 GeneCards: GRM1
Targeted by Drug
CPCCOEt,
Gene ontology Molecular function • glutamate receptor activity • G-protein coupled receptor activity • signal transducer activity • protein binding • neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration Cellular component • integral component of membrane • G-protein coupled receptor dimeric complex • postsynaptic density • membrane • G-protein coupled receptor homodimeric complex • plasma membrane • integral component of plasma membrane • dendrite • neuron projection • nucleus • presynaptic membrane Biological process • cellular response to electrical stimulus • G-protein coupled glutamate receptor signaling pathway • G-protein coupled receptor signaling pathway • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • regulation of MAPK cascade • regulation of sensory perception of pain • locomotory behavior • dimeric G-protein coupled receptor signaling pathway • activation of MAPKK activity • activation of MAPK activity • sensory perception of pain • signal transduction • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • regulation of postsynaptic cytosolic calcium ion concentration Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2911	14816
Ensembl	ENSG00000152822	ENSMUSG00000019828
UniProt	Q13255	P97772
RefSeq (mRNA)	NM_000838 NM_001114329 NM_001278064 NM_001278065 NM_001278066 NM_001278067	NM_001114333 NM_016976
RefSeq (protein)	NP_000829 NP_001264993 NP_001264994 NP_001264995 NP_001264996	NP_001107805.1 NP_058672.1 NP_001107805 NP_058672
Location (UCSC)	Chr 6: 146.03 – 146.44 Mb	Chr 10: 10.69 – 11.08 Mb
PubMed search

3KS9, 4OR2

2911

14816

ENSG00000152822

ENSMUSG00000019828

Q13255

P97772

NM_001278067

NM_001114333
NM_016976

NP_000829
NP_001264993
NP_001264994
NP_001264995
NP_001264996

NP_001107805.1
NP_058672.1
NP_001107805
NP_058672

The glutamate receptor, metabotropic 1, also known as GRM1, is a human gene which encodes the metabotropic glutamate receptor 1 (mGluR1) protein.

...
Wikipedia