Tropomyosin receptor kinase B

NTRK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4
Identifiers
Aliases	NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD
External IDs	OMIM: 600456 MGI: 97384 HomoloGene: 4504 GeneCards: NTRK2
Gene location (Human) Chr. Chromosome 9 (human) Band 9q21.33 Start 84,668,551 bp End 85,027,070 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13 B1|13 31.2 cM Start 58,806,569 bp End 59,133,970 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • neurotrophin binding • neurotrophin receptor activity • kinase activity • transmembrane receptor protein tyrosine kinase activity • ATP binding • protein kinase activity • brain-derived neurotrophic factor binding • transferase activity • protein homodimerization activity • protein tyrosine kinase activity • nucleotide binding • brain-derived neurotrophic factor-activated receptor activity • protein binding Cellular component • cytosol • endosome • postsynaptic membrane • membrane • terminal bouton • integral component of membrane • receptor complex • plasma membrane • endosome membrane • integral component of plasma membrane • postsynaptic density • early endosome • early endosome membrane Biological process • negative regulation of neuron apoptotic process • peripheral nervous system neuron development • positive regulation of protein phosphorylation • oligodendrocyte differentiation • learning • positive regulation of axonogenesis • vasculogenesis • protein phosphorylation • central nervous system neuron development • neuromuscular junction development • retinal rod cell development • circadian rhythm • feeding behavior • regulation of GTPase activity • positive regulation of peptidyl-serine phosphorylation • brain-derived neurotrophic factor receptor signaling pathway • regulation of protein kinase B signaling • regulation of metabolic process • positive regulation of MAPK cascade • cell differentiation • neurotrophin signaling pathway • phosphorylation • neuron migration • mechanoreceptor differentiation • nervous system development • glutamate secretion • retina development in camera-type eye • neuron differentiation • cerebral cortex development • negative regulation of anoikis • multicellular organism development • positive regulation of gene expression • positive regulation of cell proliferation • positive regulation of neuron projection development • cellular response to amino acid stimulus • positive regulation of phosphatidylinositol 3-kinase signaling • peptidyl-tyrosine phosphorylation • long-term synaptic potentiation • positive regulation of synapse assembly • transmembrane receptor protein tyrosine kinase signaling pathway • protein autophosphorylation • trans-synaptic signaling by neuropeptide, modulating synaptic transmission Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4915	18212
Ensembl	ENSG00000148053	ENSMUSG00000055254
UniProt	Q16620	P15209
RefSeq (mRNA)	NM_001007097 NM_001018064 NM_001018065 NM_001018066 NM_001291937 NM_006180	NM_001025074 NM_008745 NM_001282961
RefSeq (protein)	NP_001007098 NP_001018074 NP_001018075 NP_001018076 NP_001278866 NP_006171	NP_001020245 NP_001269890 NP_032771
Location (UCSC)	Chr 9: 84.67 – 85.03 Mb	Chr 9: 58.81 – 59.13 Mb
PubMed search

4AT5, 1HCF, 1WWB, 2MFQ, 4ASZ, 4AT3, 4AT4

4915

18212

ENSG00000148053

ENSMUSG00000055254

Q16620

P15209

NM_006180

NM_001025074
NM_008745
NM_001282961

NP_006171

NP_001020245
NP_001269890
NP_032771

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF).

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Wikipedia