TNFSF5

CD40LG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ALY, 1I9R, 3LKJ, 3QD6
Identifiers
Aliases	CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand
External IDs	OMIM: 300386 MGI: 88337 HomoloGene: 56 GeneCards: CD40LG
Gene ontology Molecular function • cytokine activity • CD40 receptor binding • tumor necrosis factor receptor binding • protein binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • extracellular region • external side of plasma membrane • intracellular • cell surface • extracellular space Biological process • leukocyte cell-cell adhesion • positive regulation of interleukin-12 production • regulation of immunoglobulin secretion • immunoglobulin secretion • negative regulation of apoptotic process • tumor necrosis factor-mediated signaling pathway • platelet activation • positive regulation of endothelial cell apoptotic process • B cell proliferation • isotype switching • immune response • regulation of immune response • B cell differentiation • inflammatory response • T cell costimulation • positive regulation of NF-kappaB transcription factor activity • activation of JUN kinase activity • positive regulation of interleukin-4 production • positive regulation of interleukin-10 production • positive regulation of T cell proliferation Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	959	21947
Ensembl	ENSG00000102245	ENSMUSG00000031132
UniProt	P29965	P27548
RefSeq (mRNA)	NM_000074	NM_011616
RefSeq (protein)	NP_000065	NP_035746
Location (UCSC)	Chr X: 136.65 – 136.66 Mb	Chr X: 57.21 – 57.22 Mb
PubMed search

1ALY, 1I9R, 3LKJ, 3QD6

959

21947

ENSG00000102245

ENSMUSG00000031132

P29965

P27548

NM_000074

NM_011616

NP_000065

NP_035746

CD154, also called CD40 ligand or CD40L, is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In total CD40L has three binding partners: CD40, α5β1 integrin and αIIbβ3. CD154 acts as a costimulatory molecule and is particularly important on a subset of T cells called T follicular helper cells (T_FH cells). On T_FH cells, CD154 promotes B cell maturation and function by engaging CD40 on the B cell surface and therefore facilitating cell-cell communication. A defect in this gene results in an inability to undergo immunoglobulin class switching and is associated with hyper IgM syndrome. Absence of CD154 also stops the formation of germinal centers and therefore prohibiting antibody affinity maturation, an important process in the adaptive immune system.

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Wikipedia