STAT4

STAT4
Identifiers
Aliases	STAT4, SLEB11, signal transducer and activator of transcription 4
External IDs	OMIM: 600558 MGI: 103062 HomoloGene: 20679 GeneCards: STAT4
Gene ontology Molecular function • protein binding • transcription factor activity, sequence-specific DNA binding • DNA binding • signal transducer activity Cellular component • cytoplasm • nucleus • nucleoplasm • cytosol Biological process • transcription, DNA-templated • regulation of transcription, DNA-templated • JAK-STAT cascade • signal transduction • cytokine-mediated signaling pathway • positive regulation of transcription from RNA polymerase II promoter • interleukin-12-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6775	20849
Ensembl	ENSG00000138378	ENSMUSG00000062939
UniProt	Q14765	P42228
RefSeq (mRNA)	NM_001243835 NM_003151	NM_011487 NM_001308266
RefSeq (protein)	NP_001230764 NP_003142	NP_001295195 NP_035617
Location (UCSC)	Chr 2: 191.03 – 191.15 Mb	Chr 1: 51.99 – 52.11 Mb
PubMed search

6775

20849

ENSG00000138378

ENSMUSG00000062939

Q14765

P42228

NM_001243835
NM_003151

NM_011487
NM_001308266

NP_001230764
NP_003142

NP_001295195
NP_035617

Signal transducer and activator of transcription 4 (STAT4) is a transcription factor belonging to the STAT protein family. It is required for the development of Th1 cells from naive CD4+ T cells and IFN-γ production in response to IL-12.

Human as well murine STAT4 genes lie next to STAT1 gene locus suggesting that the genes arose by gene duplication.STAT proteins have several functional domains, including an N-terminal interaction domain, a central DNA-binding domain, an SH2 domain, and the C-terminal transactivation domain.

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