Interferon-gamma

IFNG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1EKU, 1FG9, 1FYH, 1HIG, 3BES
Identifiers
Aliases	IFNG, IFG, IFI, interferon, gamma, interferon gamma
External IDs	MGI: 107656 HomoloGene: 55526 GeneCards: IFNG
Gene ontology Molecular function • interferon-gamma receptor binding • cytokine activity Cellular component • extracellular region • external side of plasma membrane • perikaryon • neuron projection • cytoplasm • extracellular space Biological process • apoptotic process • positive regulation of MHC class II biosynthetic process • negative regulation of smooth muscle cell proliferation • cellular response to interleukin-18 • movement of cell or subcellular component • antigen processing and presentation • positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity • regulation of transcription, DNA-templated • positive regulation of tumor necrosis factor (ligand) superfamily member 11 production • positive regulation of interleukin-12 production • negative regulation of growth of symbiont in host • positive regulation of autophagy • positive regulation of smooth muscle cell apoptotic process • positive regulation of chemokine biosynthetic process • regulation of insulin secretion • extrinsic apoptotic signaling pathway • regulation of the force of heart contraction • regulation of neuronal action potential • interferon-gamma-mediated signaling pathway • positive regulation of nitric oxide biosynthetic process • protein import into nucleus, translocation • positive regulation of synaptic transmission, cholinergic • response to virus • positive regulation of membrane protein ectodomain proteolysis • positive regulation of epithelial cell migration • positive regulation of osteoclast differentiation • positive regulation of killing of cells of other organism • positive regulation of calcidiol 1-monooxygenase activity • positive regulation of peptidyl-serine phosphorylation of STAT protein • negative regulation of transcription from RNA polymerase II promoter • positive regulation of vitamin D biosynthetic process • positive regulation of interleukin-6 biosynthetic process • neutrophil chemotaxis • negative regulation of gene expression • positive regulation of establishment of protein localization to plasma membrane • positive regulation of fructose 1,6-bisphosphate metabolic process • positive regulation of transcription, DNA-templated • endoplasmic reticulum unfolded protein response • positive regulation of interleukin-12 biosynthetic process • cell surface receptor signaling pathway • negative regulation of growth of symbiont involved in interaction with host • positive regulation of gene expression • regulation of interferon-gamma-mediated signaling pathway • defense response to bacterium • defense response to virus • positive regulation of interleukin-1 beta secretion • positive regulation of neuron differentiation • positive regulation of T cell proliferation • cell cycle arrest • positive regulation of cell proliferation • regulation of hepatocyte proliferation • immune response • regulation of immune response • positive regulation of tumor necrosis factor production • CD8-positive, alpha-beta T cell differentiation involved in immune response • neutrophil apoptotic process • sensory perception of mechanical stimulus • regulation of growth • positive regulation of isotype switching to IgG isotypes • positive regulation of exosomal secretion • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response • negative regulation of interleukin-17 production • cellular response to lipopolysaccharide • T cell receptor signaling pathway • negative regulation of epithelial cell differentiation • negative regulation of myelination • inflammatory cell apoptotic process • positive regulation of interleukin-23 production • response to drug • positive regulation of transcription from RNA polymerase II promoter • negative regulation of cell proliferation • positive regulation of tyrosine phosphorylation of Stat1 protein • defense response to protozoan • positive regulation of cell adhesion • negative regulation of glomerular mesangial cell proliferation • negative regulation of fibroblast proliferation • regulation of glial cell proliferation • positive regulation of apoptotic process • adaptive immune response • humoral immune response Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3458	15978
Ensembl	ENSG00000111537	ENSMUSG00000055170
UniProt	P01579	P01580
RefSeq (mRNA)	NM_000619	NM_008337
RefSeq (protein)	NP_000610	NP_032363.1 NP_032363
Location (UCSC)	Chr 12: 68.15 – 68.16 Mb	Chr 10: 118.44 – 118.45 Mb
PubMed search

Interferon gamma
Crystal structure of a biologically active single chain mutant of human interferon gamma
Identifiers
Symbol	IFN gamma
Pfam	PF00714
Pfam clan	CL0053
InterPro	IPR002069
SCOP	1rfb
SUPERFAMILY	1rfb
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Interferon gamma

Clinical data
Trade names	Actimmune
AHFS/Drugs.com	Monograph
MedlinePlus	a601152
ATC code	L03AB03 (WHO)
Identifiers
IUPAC name Human interferon gamma-1b
CAS Number	98059-61-1 Y
DrugBank	DB00033 N
ChemSpider	none
UNII	21K6M2I7AG
ChEMBL	CHEMBL1201564 N
Chemical and physical data
Formula	C761H1206N214O225S6
Molar mass	17145.6 g/mol
NY (what is this?)

1EKU, 1FG9, 1FYH, 1HIG, 3BES

3458

15978

ENSG00000111537

ENSMUSG00000055170

P01579

P01580

NM_000619

NM_008337

NP_000610

NP_032363.1
NP_032363

Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class of interferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.