STAT1

STAT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WWT, 1BF5, 1YVL, 2KA6
Identifiers
Aliases	STAT1, CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91, signal transducer and activator of transcription 1
External IDs	MGI: 103063 HomoloGene: 21428 GeneCards: STAT1
Gene ontology Molecular function • DNA binding • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter sequence-specific • signal transducer activity • RNA polymerase II core promoter proximal region sequence-specific DNA binding • protein binding • identical protein binding • enzyme binding • tumor necrosis factor receptor binding • double-stranded DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • nuclear hormone receptor binding • cadherin binding Cellular component • cytoplasm • nucleoplasm • nucleolus • perinuclear region of cytoplasm • nuclear chromatin • nucleus • cytosol • axon • dendrite Biological process • regulation of apoptotic process • metanephric mesenchymal cell proliferation involved in metanephros development • regulation of transcription, DNA-templated • cellular response to interferon-beta • interferon-gamma-mediated signaling pathway • regulation of transcription from RNA polymerase II promoter • negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis • metanephric mesenchymal cell differentiation • tumor necrosis factor-mediated signaling pathway • negative regulation of transcription from RNA polymerase II promoter • renal tubule development • response to interferon-beta • negative regulation of I-kappaB kinase/NF-kappaB signaling • transcription, DNA-templated • negative regulation of endothelial cell proliferation • positive regulation of transcription, DNA-templated • regulation of type I interferon-mediated signaling pathway • regulation of interferon-gamma-mediated signaling pathway • defense response to virus • type I interferon signaling pathway • positive regulation of mesenchymal cell proliferation • negative regulation of metanephric nephron tubule epithelial cell differentiation • negative regulation of angiogenesis • negative regulation by virus of viral protein levels in host cell • viral process • endothelial cell migration • positive regulation of transcription from RNA polymerase II promoter • signal transduction • apoptotic process • macrophage derived foam cell differentiation • JAK-STAT cascade • blood circulation • response to cytokine • response to peptide hormone • positive regulation of smooth muscle cell proliferation • response to cAMP Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6772	20846
Ensembl	ENSG00000115415	ENSMUSG00000026104
UniProt	P42224	P42225
RefSeq (mRNA)	NM_007315 NM_139266	NM_001205313 NM_001205314 NM_009283
RefSeq (protein)	NP_009330 NP_644671	n/a
Location (UCSC)	Chr 2: 190.96 – 191.02 Mb	Chr 1: 52.12 – 52.16 Mb
PubMed search

3WWT, 1BF5, 1YVL, 2KA6

6772

20846

ENSG00000115415

ENSMUSG00000026104

P42224

P42225

NM_007315
NM_139266

NM_001205313
NM_001205314
NM_009283

NP_009330
NP_644671

n/a

Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.

STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon-Stimulated Genes).

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Wikipedia