STAT2

STAT2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KA4
Identifiers
Aliases	STAT2, ISGF-3, P113, STAT113, IMD44, signal transducer and activator of transcription 2
External IDs	MGI: 103039 HomoloGene: 3952 GeneCards: STAT2
Gene ontology Molecular function • DNA binding • transcription factor activity, sequence-specific DNA binding • signal transducer activity • protein binding • identical protein binding Cellular component • plasma membrane • nucleoplasm • nucleus • cytoplasm • cytosol Biological process • JAK-STAT cascade • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • regulation of type I interferon-mediated signaling pathway • viral process • signal transduction • regulation of protein phosphorylation • defense response to virus • regulation of mitochondrial fission • type I interferon signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6773	20847
Ensembl	ENSG00000170581	ENSMUSG00000040033
UniProt	P52630	Q9WVL2
RefSeq (mRNA)	NM_005419 NM_198332	NM_019963
RefSeq (protein)	NP_005410 NP_938146	n/a
Location (UCSC)	Chr 12: 56.34 – 56.36 Mb	Chr 10: 128.27 – 128.29 Mb
PubMed search

2KA4

6773

20847

ENSG00000170581

ENSMUSG00000040033

P52630

Q9WVL2

NM_005419
NM_198332

NM_019963

NP_005410
NP_938146

n/a

Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family.

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (IRF9), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.

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