ROCK2

ROCK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4L6Q, 4WOT
Identifiers
Aliases	ROCK2, ROCK-II, Rho associated coiled-coil containing protein kinase 2
External IDs	MGI: 107926 HomoloGene: 21010 GeneCards: ROCK2
Gene ontology Molecular function • transferase activity • nucleotide binding • protein kinase activity • structural molecule activity • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • Rho GTPase binding • ATP binding • Rho-dependent protein serine/threonine kinase activity • RNA binding Cellular component • cytoplasm • centrosome • membrane • plasma membrane • microtubule organizing center • cytoplasmic ribonucleoprotein granule • cytoskeleton • nucleus • cytosol • intracellular Biological process • smooth muscle contraction • positive regulation of protein phosphorylation • intracellular signal transduction • regulation of actin cytoskeleton organization • centrosome duplication • phosphorylation • rhythmic process • ephrin receptor signaling pathway • cellular response to testosterone stimulus • cytokinesis • positive regulation of centrosome duplication • regulation of stress fiber assembly • regulation of cell motility • positive regulation of endothelial cell migration • protein phosphorylation • negative regulation of bicellular tight junction assembly • vascular endothelial growth factor receptor signaling pathway • positive regulation of gene expression • regulation of cell adhesion • regulation of circadian rhythm • Rho protein signal transduction • regulation of focal adhesion assembly • negative regulation of angiogenesis • regulation of keratinocyte differentiation • negative regulation of myosin-light-chain-phosphatase activity • I-kappaB kinase/NF-kappaB signaling • regulation of establishment of cell polarity • cortical actin cytoskeleton organization • regulation of establishment of endothelial barrier • actin cytoskeleton organization • viral RNA genome replication • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9475	19878
Ensembl	ENSG00000134318	ENSMUSG00000020580
UniProt	O75116	P70336
RefSeq (mRNA)	NM_004850 NM_001321643	NM_009072
RefSeq (protein)	NP_001308572 NP_004841	NP_033098
Location (UCSC)	Chr 2: 11.18 – 11.35 Mb	Chr 12: 16.89 – 16.99 Mb
PubMed search

4L6Q, 4WOT

9475

19878

ENSG00000134318

ENSMUSG00000020580

O75116

P70336

NM_004850
NM_001321643

NM_009072

NP_001308572
NP_004841

NP_033098

Rho associated coiled-coil containing protein kinase 2 is a protein that in humans is encoded by the ROCK2 gene.

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

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Wikipedia