ROCK1

ROCK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML
Identifiers
Aliases	ROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1
External IDs	MGI: 107927 HomoloGene: 55899 GeneCards: ROCK1
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • metal ion binding • kinase activity • protein serine/threonine kinase activity • protein binding • Rho GTPase binding • GTP-Rho binding • ATP binding Cellular component • cytoplasm • cytosol • Golgi apparatus • cell projection • membrane • ruffle • Golgi membrane • plasma membrane • bleb • centriole • cytoskeleton • lamellipodium • extracellular region • secretory granule lumen Biological process • negative regulation of neuron apoptotic process • leukocyte cell-cell adhesion • smooth muscle contraction • myoblast migration • intracellular signal transduction • regulation of actin cytoskeleton organization • phosphorylation • ephrin receptor signaling pathway • bleb assembly • negative regulation of protein binding • regulation of actin filament-based process • regulation of stress fiber assembly • regulation of cell motility • protein phosphorylation • negative regulation of bicellular tight junction assembly • vascular endothelial growth factor receptor signaling pathway • regulation of cell adhesion • Rho protein signal transduction • membrane to membrane docking • leukocyte tethering or rolling • regulation of focal adhesion assembly • negative regulation of angiogenesis • regulation of keratinocyte differentiation • positive regulation of focal adhesion assembly • negative regulation of myosin-light-chain-phosphatase activity • I-kappaB kinase/NF-kappaB signaling • regulation of establishment of cell polarity • cortical actin cytoskeleton organization • apical constriction • regulation of establishment of endothelial barrier • actin cytoskeleton organization • leukocyte migration • signal transduction • regulation of cytoskeleton organization • apoptotic process • neutrophil degranulation • execution phase of apoptosis • protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6093	19877
Ensembl	ENSG00000067900	ENSMUSG00000024290
UniProt	Q13464	P70335
RefSeq (mRNA)	NM_005406	NM_009071
RefSeq (protein)	NP_005397	NP_033097
Location (UCSC)	Chr 18: 20.95 – 21.11 Mb	Chr 18: 10.06 – 10.18 Mb
PubMed search

1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML

6093

19877

ENSG00000067900

ENSMUSG00000024290

Q13464

P70335

NM_005406

...
Wikipedia