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Serum response element

SRF
PBB Protein SRF image.jpg
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SRF, MCM1, serum response factor
External IDs MGI: 106658 HomoloGene: 31135 GeneCards: SRF
RNA expression pattern
PBB GE SRF 202400 s at fs.png

PBB GE SRF 202401 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003131
NM_001292001

NM_020493

RefSeq (protein)

NP_001278930
NP_003122
NP_003122.1

NP_065239

Location (UCSC) Chr 6: 43.17 – 43.18 Mb Chr 17: 46.55 – 46.56 Mb
PubMed search

1HBX, 1K6O, 1SRS

NM_003131
NM_001292001

NM_020493

NP_001278930
NP_003122
NP_003122.1

NP_065239

Serum response factor, also known as SRF, is a transcription factor protein.

Serum response factor is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs).


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Wikipedia

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