C-fos

FOS
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A02, 1FOS, 1S9K
Identifiers
Aliases	FOS, AP-1, C-p55, Fos proto-oncogene, AP-1 trancription factor subunit, Fos proto-oncogene, AP-1 transcription factor subunit
External IDs	OMIM: 164810 MGI: 95574 HomoloGene: 3844 GeneCards: FOS
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • R-SMAD binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • chromatin binding • protein binding • protein heterodimerization activity • transcription regulatory region DNA binding • double-stranded DNA binding • RNA polymerase II core promoter sequence-specific DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding Cellular component • cytoplasm • cytosol • membrane • transcription factor complex • nucleoplasm • endoplasmic reticulum • neuron projection • nucleus Biological process • cellular response to extracellular stimulus • response to muscle stretch • response to immobilization stress • cellular response to calcium ion • response to cytokine • regulation of transcription, DNA-templated • SMAD protein signal transduction • response to organic cyclic compound • response to light stimulus • regulation of transcription from RNA polymerase II promoter • response to progesterone • female pregnancy • response to corticosterone • response to mechanical stimulus • aging • positive regulation of osteoclast differentiation • transcription from RNA polymerase II promoter • nervous system development • cellular response to reactive oxygen species • response to gravity • Fc-epsilon receptor signaling pathway • positive regulation of transcription, DNA-templated • DNA methylation • response to lipopolysaccharide • sleep • cellular response to hormone stimulus • regulation of sequence-specific DNA binding transcription factor activity • conditioned taste aversion • skeletal muscle cell differentiation • response to cold • response to cAMP • inflammatory response • transforming growth factor beta receptor signaling pathway • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • response to toxic substance • response to drug • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2353	14281
Ensembl	ENSG00000170345	ENSMUSG00000021250
UniProt	P01100 Q6FG41	P01101
RefSeq (mRNA)	NM_005252	NM_010234
RefSeq (protein)	NP_005243 NP_005243.1	NP_034364.1 NP_034364
Location (UCSC)	Chr 14: 75.28 – 75.28 Mb	Chr 12: 85.47 – 85.48 Mb
PubMed search

1A02, 1FOS, 1S9K

2353

14281

ENSG00000170345

ENSMUSG00000021250

P01100
Q6FG41

P01101

NM_005252

NM_010234

NP_005243
NP_005243.1

NP_034364.1
NP_034364

In the fields of molecular biology and genetics, c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus). It is a part of a bigger Fos family of transcription factors which includes c-Fos, FosB, Fra-1 and Fra-2. It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers.

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