Fra-2

FOSL2
Identifiers
Aliases	FOSL2, Fos-Related Antigen, FRA-2, FRA2, FOS like 2, AP-1 transcription factor subunit
External IDs	MGI: 102858 HomoloGene: 3845 GeneCards: FOSL2
Gene location (Human) Chr. Chromosome 2 (human) Band No data available Start 28,392,448 bp End 28,417,312 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band No data available Start 32,135,801 bp End 32,157,842 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • DNA binding • chromatin binding • protein binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding Cellular component • nucleus • nucleoplasm Biological process • regulation of transcription from RNA polymerase II promoter • positive regulation of transcription, DNA-templated • keratinocyte development • cell death • regulation of transcription, DNA-templated • transcription, DNA-templated • positive regulation of fibroblast proliferation • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2355	14284
Ensembl	ENSG00000075426	ENSMUSG00000029135
UniProt	P15408	P47930
RefSeq (mRNA)	NM_005253	NM_008037
RefSeq (protein)	NP_005244	NP_032063
Location (UCSC)	Chr 2: 28.39 – 28.42 Mb	Chr 2: 32.14 – 32.16 Mb
PubMed search

2355

14284

ENSG00000075426

ENSMUSG00000029135

P15408

P47930

NM_005253

NM_008037

NP_005244

NP_032063

Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene.

The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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