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C-Fos

FOS
1a02.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases FOS, AP-1, C-p55, Fos proto-oncogene, AP-1 trancription factor subunit, Fos proto-oncogene, AP-1 transcription factor subunit
External IDs OMIM: 164810 MGI: 95574 HomoloGene: 3844 GeneCards: FOS
RNA expression pattern
PBB GE FOS 209189 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005252

NM_010234

RefSeq (protein)

NP_005243
NP_005243.1

NP_034364.1
NP_034364

Location (UCSC) Chr 14: 75.28 – 75.28 Mb Chr 12: 85.47 – 85.48 Mb
PubMed search

1A02, 1FOS, 1S9K

NM_005252

NM_010234

NP_005243
NP_005243.1

NP_034364.1
NP_034364

In the fields of molecular biology and genetics, c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus). It is a part of a bigger Fos family of transcription factors which includes c-Fos, FosB, Fra-1 and Fra-2. It has been mapped to chromosome region 14q21→q31. c-Fos encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers.


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Wikipedia

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