FOSB

FOSB
Identifiers
Aliases	FOSB, AP-1, G0S3, GOS3, GOSB, FosB, ΔFosB, FosB proto-oncogene, AP-1 transcription factor subunit
External IDs	MGI: 95575 HomoloGene: 31403 GeneCards: FOSB
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • transcription factor binding • double-stranded DNA binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding Cellular component • nucleoplasm • intracellular membrane-bounded organelle • nucleus Biological process • cellular response to calcium ion • regulation of transcription, DNA-templated • regulation of transcription from RNA polymerase II promoter • response to progesterone • female pregnancy • response to corticosterone • response to mechanical stimulus • negative regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • response to morphine • cellular response to hormone stimulus • response to cAMP • response to drug • positive regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2354	14282
Ensembl	ENSG00000125740	ENSMUSG00000003545
UniProt	P53539	P13346
RefSeq (mRNA)	NM_001114171 NM_006732	NM_008036 NM_001347586
RefSeq (protein)	NP_001107643 NP_006723	NP_032062.1 NP_001334515 NP_032062
Location (UCSC)	Chr 19: 45.47 – 45.48 Mb	Chr 7: 19.3 – 19.31 Mb
PubMed search

2354

14282

ENSG00000125740

ENSMUSG00000003545

P53539

P13346

NM_001114171
NM_006732

NM_008036
NM_001347586

NP_001107643
NP_006723

NP_032062.1
NP_001334515
NP_032062

FBJ murine osteosarcoma viral oncogene homolog B, also known as FOSB or FosB, is a protein that, in humans, is encoded by the FOSB gene.

The FOS gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. FosB and its truncated splice variants ΔFosB and (further truncated) Δ2ΔFosB are all involved in osteosclerosis, even though Δ2ΔFosB lacks a known transactivation domain, preventing it from affecting gene transcription through the AP-1 complex.

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Wikipedia