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C-Jun

JUN
1a02.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit
External IDs OMIM: 165160 MGI: 96646 HomoloGene: 1679 GeneCards: JUN
RNA expression pattern
PBB GE JUN 201464 x at tn.png

PBB GE JUN 201465 s at tn.png

PBB GE JUN 201466 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002228

NM_010591

RefSeq (protein)

NP_002219

NP_034721.1
NP_034721

Location (UCSC) Chr 1: 58.78 – 58.78 Mb Chr 4: 95.05 – 95.05 Mb
PubMed search

1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS

NM_002228

NM_010591

NP_002219

NP_034721.1
NP_034721

c-Jun is a protein that in humans is encoded by the JUN gene. c-Jun in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-jun knockout is lethal, but transgenic animals with a mutated c-jun that cannot be phosphorylated (termed c-junAA) can survive.


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Wikipedia

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