C-Jun

JUN
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS
Identifiers
Aliases	JUN, AP-1, AP1, c-Jun, Jun proto-oncogene, AP-1 transcription factor subunit
External IDs	OMIM: 165160 MGI: 96646 HomoloGene: 1679 GeneCards: JUN
Gene ontology Molecular function • GTPase activator activity • transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding • RNA polymerase II activating transcription factor binding • transcription regulatory region DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • cAMP response element binding • R-SMAD binding • HMG box domain binding • transcription factor binding • activating transcription factor binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding • enzyme binding • RNA polymerase II distal enhancer sequence-specific DNA binding • protein homodimerization activity • chromatin binding • transcriptional activator activity, RNA polymerase II transcription factor binding • protein binding • double-stranded DNA binding • DNA binding • sequence-specific DNA binding • transcription coactivator activity • identical protein binding • protein heterodimerization activity • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • RNA binding Cellular component • cytosol • transcriptional repressor complex • nucleus • nuclear chromosome • nuclear chromatin • transcription factor complex • nucleoplasm • nuclear euchromatin Biological process • negative regulation of neuron apoptotic process • negative regulation of DNA binding • outflow tract morphogenesis • transcription from RNA polymerase II promoter • learning • monocyte differentiation • response to organic substance • leading edge cell differentiation • Fc-epsilon receptor signaling pathway • positive regulation of neuron apoptotic process • cellular response to hormone stimulus • regulation of sequence-specific DNA binding transcription factor activity • circadian rhythm • angiogenesis • positive regulation of ERK1 and ERK2 cascade • Ras protein signal transduction • transforming growth factor beta receptor signaling pathway • negative regulation of cell proliferation • response to muscle stretch • cellular response to calcium ion • response to cytokine • regulation of transcription, DNA-templated • SMAD protein signal transduction • axon regeneration • SMAD protein import into nucleus • positive regulation of fibroblast proliferation • response to mechanical stimulus • positive regulation of epithelial cell migration • positive regulation of DNA-templated transcription, initiation • transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of cell differentiation • positive regulation of monocyte differentiation • positive regulation of pri-miRNA transcription from RNA polymerase II promoter • negative regulation of protein autophosphorylation • regulation of cell death • membrane depolarization • negative regulation of apoptotic process • eyelid development in camera-type eye • microglial cell activation • positive regulation of DNA replication • negative regulation by host of viral transcription • response to lipopolysaccharide • response to radiation • response to cAMP • negative regulation of transcription, DNA-templated • response to hydrogen peroxide • positive regulation by host of viral transcription • positive regulation of smooth muscle cell proliferation • positive regulation of endothelial cell proliferation • response to organic cyclic compound • aging • regulation of cell cycle • regulation of cell proliferation • positive regulation of cell proliferation • positive regulation of apoptotic process • liver development • negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress • cellular response to potassium ion starvation • response to drug • cellular process • release of cytochrome c from mitochondria • positive regulation of transcription from RNA polymerase II promoter • positive regulation of GTPase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3725	16476
Ensembl	ENSG00000177606	ENSMUSG00000052684
UniProt	P05412	P05627
RefSeq (mRNA)	NM_002228	NM_010591
RefSeq (protein)	NP_002219	NP_034721.1 NP_034721
Location (UCSC)	Chr 1: 58.78 – 58.78 Mb	Chr 4: 95.05 – 95.05 Mb
PubMed search

1A02, 1JNM, 1JUN, 1S9K, 1T2K, 1FOS

3725

16476

ENSG00000177606

ENSMUSG00000052684

P05412

P05627

NM_002228

NM_010591

NP_002219

NP_034721.1
NP_034721

c-Jun is a protein that in humans is encoded by the JUN gene. c-Jun in combination with c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39 and only later rediscovered as the product of the c-jun gene. It is activated through double phosphorylation by the JNK pathway but has also a phosphorylation-independent function. c-jun knockout is lethal, but transgenic animals with a mutated c-jun that cannot be phosphorylated (termed c-junAA) can survive.

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