Qutlugh Nigar Khanum (also spelled Kutlak Nigar Khanum; d. 1505) was the first wife and chief consort of Umar Shaikh Mirza II, the ruler of Ferghana Valley. She was a princess of Moghulistan by birth and was a daughter of Yunus Khan, the Great Khan of Moghulistan.

She was also the mother of Emperor Babur, the founder of the Mughal Empire of India as well as its first emperor.

Qutlugh Nigar Khanum was born a princess of Moghulistan and was the second daughter of Yunus Khan, the Great Khan of Moghulistan, and his chief consort Aisan Daulat Begum. Her paternal grandfather was Uwais Khan, the Moghul Khan of Moghulistan and her father's predecessor.

Qutlugh was a direct descendant of Genghis Khan, the founder and Great Khan (Emperor) of the Mongol Empire through her father's side. Being the daughter of a Khan, Qutlugh held the title of "Khanum" ("daughter of a Khan or princess") by birth.

All of Qutlugh's siblings became her sisters-in-law since her elder sister, Mihr Nigar Khanum, married Sultan Ahmed Mirza, the eldest son of Abu Sa'id Mirza. Her younger sister, Khub Nigar Khanum, married Sultan Ahmed Mirza's successor, Sultan Mahmud Mirza.

Qutlugh married Prince Umar Shaikh, the fourth son of Abu Sa'id Mirza, the Emperor of the Timurid Empire in 1475. She was his first wife and chief consort. Before his death, her father-in-law had divided his empire between his sons and Umar was given to rule Ferghana Valley in today's Uzbekistan. Here, at Andizhan, she gave birth to Umar's eldest son, Prince Babur on 14 February 1483. Babur went on to become the founder of the Mughal Empire of India and was the first Mughal emperor.

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