Prostaglandin F receptor

PTGFR
Identifiers
Aliases	PTGFR, FP, Prostaglandin F receptor
External IDs	MGI: 97796 HomoloGene: 741 GeneCards: PTGFR
Targeted by Drug
tafluprost, bimatoprost, latanoprost, prostaglandin D2, dinoprostone, dinoprost, sulprostone, U46619
Gene ontology Molecular function • prostaglandin F receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • cytoplasm • integral component of membrane • extracellular region • plasma membrane • integral component of plasma membrane • membrane Biological process • G-protein coupled receptor signaling pathway • response to lipopolysaccharide • positive regulation of gene expression • response to estradiol • negative regulation of apoptotic process • cellular response to prostaglandin D stimulus • calcium-mediated signaling using intracellular calcium source • parturition • positive regulation of cell proliferation • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5737	19220
Ensembl	ENSG00000122420	ENSMUSG00000028036
UniProt	P43088	P43117
RefSeq (mRNA)	NM_000959 NM_001039585	NM_008966
RefSeq (protein)	NP_000950 NP_001034674	NP_032992.1 NP_032992
Location (UCSC)	Chr 1: 78.3 – 78.54 Mb	Chr 3: 151.8 – 151.84 Mb
PubMed search

5737

19220

ENSG00000122420

ENSMUSG00000028036

P43088

P43117

NM_000959
NM_001039585

NM_008966

NP_000950
NP_001034674

NP_032992.1
NP_032992

Prostaglandin F receptor (FP) is a receptor belonging to the prostaglandin (PG) group of receptors. FP binds to and mediates the biological actions of Prostaglandin F_2α (PGF_2α). It is encoded in humans by the PTGFR gene.

The PTGFR gene is located on human chromosome 1 at position p31.1 (i.e. 1p31.1), contains 7 exons, and codes for a G protein coupled receptor (GPCR) of the rhodopsin-like receptor family, Subfamily A14 (see rhodopsin-like receptors#Subfamily A14). PTGFR is expressed as two alternatively spliced transcript variants encoding different isoforms, FP_A and FP_B, which have different C-terminal lengths.MicroRNA miR-590-3p binds to the Three prime untranslated region of the FP gene to repress its translation. miR-590-3p thus appears to be a negative regulator of FP expression in various cell types.

...
Wikipedia