Don Carlos, Prince of Bourbon-Two Sicilies, Infante of Spain (Full Italian name: Carlo Maria Francesco d'Assisi Pasquale Ferdinando Antonio di Padova Francesco de Paola Alfonso Andrea Avelino Tancredi, Principe di Borbone delle Due Sicilie, Infante di Spagna) (10 November 1870, Gries-San Quirino (), Bolzano, Italy – 11 November 1949, Seville, Spain) was the son of Prince Alfonso of the Two Sicilies, Count of Caserta and his wife Princess Maria Antonietta of Bourbon-Two Sicilies, and nephew of the last King of the Two Sicilies, Francis II.

On 14 February 1901 in Madrid, Carlos married Mercedes, Princess of Asturias, elder daughter of the late King Alfonso XII of Spain and of his wife Archduchess Maria Christina of Austria. Mercedes was the elder sister and heiress presumptive to King Alfonso XIII of Spain, an unmarried teenager. A week before the wedding, on 7 February, Carlos was given the title of Infante of Spain.

Carlos and Mercedes had three children:

Mercedes died in childbirth in 1904.

In 1907, Carlos married secondly to Princess Louise of Orléans, daughter of Prince Philippe, Count of Paris. The couple had four children: