Francis II (Italian: Francesco II, christened Francesco d'Assisi Maria Leopoldo, 16 January 1836 – 27 December 1894) was King of the Two Sicilies from 1859 to 1861. He was the last King of the Two Sicilies, as successive invasions by Giuseppe Garibaldi and Victor Emmanuel II of Sardinia ultimately brought an end to his rule, as part of Italian unification. After he was deposed, the Kingdom of the Two Sicilies and the Kingdom of Sardinia were merged into the newly formed Kingdom of Italy.

The only son and heir of Ferdinand II of the Two Sicilies by his first wife, Maria Christina of Savoy, Francis II was the last of the Bourbon kings of Naples, where he was born in 1836. His education had been much neglected and he proved a man of weak character, greatly influenced by his stepmother Archduchess Maria Theresa of Austria, whom he feared, and also by the priests, and by the camarilla, or reactionary court set.

On 3 February 1859 in Bari, Francis married princess Duchess Maria Sophia in Bavaria, of the royal Bavarian house of Wittelsbach (a younger sister of Empress Elisabeth "Sissi" of Austria). Their only daughter, Maria Cristina, lived only three months (24 December 1869 – 28 March 1870).

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