Pittsburgh to St. Louis Main Line

The Pittsburgh to St. Louis Main Line was a rail line owned and operated by the Pennsylvania Railroad in the U.S. states of Pennsylvania, Ohio, Indiana, and Illinois. The line ran from Pittsburgh, Pennsylvania west via Steubenville, Ohio, Columbus, Ohio, Dayton, Ohio, Indianapolis, Indiana, Terre Haute, Indiana, and Vandalia, Illinois to East St. Louis, Illinois. In addition to its east end in downtown Pittsburgh, where it met the Main Line and Pittsburgh to Chicago Main Line, junctions included the Columbus to Chicago Main Line at Columbus, the C&X Branch (to Cincinnati) at Xenia, the Columbus to Indianapolis Main Line via Bradford (a freight bypass of Dayton) at New Paris, the Richmond Branch and Fort Wayne Branch at Richmond, the Louisville Branch and I&F Branch at Indianapolis, and the Peoria Branch at Farrington, Illinois.

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