Pentagastrin

Pentagastrin

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	V04CG04 (WHO)
Pharmacokinetic data
Biological half-life	10 minutes or less
Identifiers
IUPAC name N-(tert-butoxycarbonyl)-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-L-phenylalaninamide
CAS Number	5534-95-2 Y
PubChem CID	9853654
IUPHAR/BPS	870
DrugBank	DB00183 Y
ChemSpider	8029364 Y
UNII	EF0NX91490
KEGG	D01631 Y
ChEMBL	CHEMBL1328 Y
ECHA InfoCard	100.024.445
Chemical and physical data
Formula	C37H49N7O9S
Molar mass	767.893 g/mol
3D model (Jmol)	Interactive image
SMILES O=C(N)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCNC(=O)OC(C)(C)C)Cc2c1ccccc1[nH]c2)CCSC)CC(=O)O)Cc3ccccc3
InChI InChI=1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)/t26-,27-,28-,29-/m0/s1 Y Key:NEYNJQRKHLUJRU-DZUOILHNSA-N Y

Pentagastrin (trade name Peptavlon) is a synthetic polypeptide that has effects like gastrin when given . It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it may cause panic attacks.

Pentagastrin's IUPAC chemical name is "N-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide".

Pentagastrin is also used as a stimulation test to elevate of several hormones, such as serotonin. It provokes flushing and is useful in evaluating patients who describe flushing, but have normal or only marginally elevated biochemical markers for carcinoid syndrome.

It has been used to stimulate ectopic gastric mucosa for the detection of Meckels diverticulum by nuclear medicine.

It is used to stimulate calcitonin release from residual parafollicular cell C-cells after total thyroidectomy for medullary thyroid carcinoma.