Calcitonin

CALCA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2JXZ,%%s1LS7
Identifiers
Aliases	CALCA, CALC1, CGRP, CGRP-I, CGRP1, CT, KC, PCT, calcitonin related polypeptide alpha, Calcitonin
External IDs	OMIM: 114130 HomoloGene: 88401 GeneCards: CALCA
Targeted by Drug
Gene ontology Molecular function • hormone activity • calcitonin receptor binding • protein binding • identical protein binding • receptor binding • protein complex binding Cellular component • cytoplasm • intracellular • extracellular region • axon • terminal bouton • neuronal cell body • neuron projection • nucleus • extracellular space Biological process • cellular protein metabolic process • cellular response to nerve growth factor stimulus • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway • positive regulation of adenylate cyclase activity • negative regulation of smooth muscle contraction • regulation of heart contraction • adenylate cyclase-activating G-protein coupled receptor signaling pathway • monocyte chemotaxis • negative regulation of blood pressure • positive regulation of cytosolic calcium ion concentration • cellular response to tumor necrosis factor • aging • vasodilation • cellular calcium ion homeostasis • response to heat • negative regulation of neurological system process • positive regulation of ossification • activation of adenylate cyclase activity • regulation of heart rate • detection of temperature stimulus involved in sensory perception of pain • negative regulation of ossification • response to pain • vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure • feeding behavior • inflammatory response • neuropeptide signaling pathway • negative regulation of transcription, DNA-templated • activation of protein kinase activity • embryo implantation • negative regulation of bone resorption • leukocyte cell-cell adhesion • positive regulation of cAMP biosynthetic process • G-protein coupled receptor internalization • positive regulation of interleukin-1 alpha production • response to yeast • regulation of cytosolic calcium ion concentration • negative regulation of osteoclast differentiation • positive regulation of vasodilation • cell-cell signaling • antibacterial humoral response • positive regulation of macrophage differentiation • receptor internalization • regulation of blood pressure • protein phosphorylation • vasculature development • defense response to Gram-negative bacterium • endothelial cell proliferation • positive regulation of interleukin-8 production • neurological system process involved in regulation of systemic arterial blood pressure • negative regulation of calcium ion transport into cytosol • innate immune response • endothelial cell migration • antifungal humoral response • defense response to Gram-positive bacterium Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	796	n/a
Ensembl	ENSG00000110680	n/a
UniProt	P01258 P06881	n/a
RefSeq (mRNA)	NM_001033952 NM_001033953 NM_001741	n/a
RefSeq (protein)	NP_001029124.1 NP_001732.1 NP_001029125.1	n/a
Location (UCSC)	Chr 11: 14.97 – 14.97 Mb	n/a
PubMed search		n/a

2JXZ,%%s1LS7

796

n/a

ENSG00000110680

n/a

P01258
P06881

n/a

NM_001033952
NM_001033953
NM_001741

n/a

NP_001029124.1
NP_001732.1
NP_001029125.1

n/a

Calcitonin (also known as thyrocalcitonin) is a 32-amino acid linear polypeptide hormone that is produced in humans primarily by the parafollicular cells (also known as C-cells) of the thyroid, and in many other animals in the ultimopharyngeal body. It acts to reduce blood calcium (Ca²⁺), opposing the effects of parathyroid hormone (PTH).

Calcitonin has been found in fish, reptiles, birds, and mammals. Its importance in humans has not been as well established as its importance in other animals, as its function is usually not significant in the regulation of normal calcium homeostasis. It belongs to the calcitonin-like protein family.

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