PRSS1

PRSS1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1FXY, 1TRN, 2RA3, 4WWY, 4WXV
Identifiers
Aliases	PRSS1, TRP1, TRY1, TRY4, TRYP1, Trypsin 1, protease, serine 1
External IDs	MGI: 3687012 HomoloGene: 134623 GeneCards: PRSS1
Targeted by Drug
camostat, nafamostat
Gene ontology Molecular function • peptidase activity • serine-type endopeptidase activity • hydrolase activity • metal ion binding • serine-type peptidase activity Cellular component • extracellular region • blood microparticle • extracellular exosome • extracellular space Biological process • digestion • cobalamin metabolic process • extracellular matrix disassembly • proteolysis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5644	436522
Ensembl	n/a	ENSMUSG00000071521
UniProt	P07477	n/a
RefSeq (mRNA)	NM_002769	NM_001038996
RefSeq (protein)	NP_002760	n/a
Location (UCSC)	Chr 7: 142.75 – 142.76 Mb	Chr 6: 41.35 – 41.36 Mb
PubMed search

1FXY, 1TRN, 2RA3, 4WWY, 4WXV

5644

436522

n/a

ENSMUSG00000071521

P07477

n/a

NM_002769

NM_001038996

NP_002760

n/a

Trypsin-1, also known as cationic trypsinogen, is a protein that in humans is encoded by the PRSS1 gene. Trypsin-1 is the main isoform of trypsinogen secreted by pancreas, the others are trypsin-2 (anionic trypsinogen), and trypsin-3 (meso-trypsinogen).

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7.

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Wikipedia