PRSS2

PRSS2
Identifiers
Aliases	PRSS2, TRY2, TRY8, TRYP2, protease, serine 2
External IDs	MGI: 102759 HomoloGene: 122141 GeneCards: PRSS2
Gene ontology Molecular function • calcium ion binding • peptidase activity • protein binding • hydrolase activity • metal ion binding • serine-type endopeptidase activity • serine-type peptidase activity • metalloendopeptidase activity Cellular component • extracellular matrix • extracellular region • extracellular space • azurophil granule lumen Biological process • collagen catabolic process • digestion • positive regulation of cell growth • extracellular matrix disassembly • proteolysis • positive regulation of cell adhesion • antimicrobial humoral response • neutrophil degranulation Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5645	22072
Ensembl	n/a	ENSMUSG00000057163
UniProt	P07478	P07146
RefSeq (mRNA)	NM_001303414 NM_002770	NM_009430
RefSeq (protein)	NP_001290343 NP_002761	NP_033456.1 NP_033456
Location (UCSC)	Chr 7: 142.75 – 142.77 Mb	Chr 6: 41.52 – 41.53 Mb
PubMed search

5645

22072

n/a

ENSMUSG00000057163

P07478

P07146

NM_001303414
NM_002770

NM_009430

NP_001290343
NP_002761

NP_033456.1
NP_033456

Protease, serine, 2 (trypsin 2) is a protein that in humans is encoded by the PRSS2 gene.

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].

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