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Trypsin

Trypsin
Identifiers
EC number 3.4.21.4
CAS number 9002-07-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Trypsin
1UTN.png
Identifiers
Symbol Trypsin
Pfam PF00089
InterPro IPR001254
SMART SM00020
PROSITE PDOC00124
MEROPS S1
SCOP 1c2g
SUPERFAMILY 1c2g
CDD cd00190
protease, serine, 1 (trypsin 1)
Identifiers
Symbol PRSS1
Alt. symbols TRY1
Entrez 5644
HUGO 9475
OMIM 276000
RefSeq NM_002769
UniProt P07477
Other data
EC number 3.4.21.4
Locus Chr. 7 q32-qter
protease, serine, 2 (trypsin 2)
Identifiers
Symbol PRSS2
Alt. symbols TRYP2
Entrez 5645
HUGO 9483
OMIM 601564
RefSeq NM_002770
UniProt P07478
Other data
EC number 3.4.21.4
Locus Chr. 7 q35
protease, serine, 3 (mesotrypsin)
Identifiers
Symbol PRSS3
Alt. symbols PRSS4
Entrez 5646
HUGO 9486
OMIM 613578
RefSeq NM_002771
UniProt P35030
Other data
EC number 3.4.21.4
Locus Chr. 9 p13

Trypsin (EC 3.4.21.4) is a serine protease from the PA clan superfamily, found in the digestive system of many vertebrates, where it hydrolyses proteins. Trypsin is formed in the small intestine when its proenzyme form, the trypsinogen produced by the pancreas, is activated. Trypsin cleaves peptide chains mainly at the carboxyl side of the amino acids lysine or arginine, except when either is followed by proline. It is used for numerous biotechnological processes. The process is commonly referred to as trypsin proteolysis or trypsinisation, and proteins that have been digested/treated with trypsin are said to have been trypsinized.

In the duodenum, trypsin catalyzes the hydrolysis of peptide bonds, breaking down proteins into smaller peptides. The peptide products are then further hydrolyzed into amino acids via other proteases, rendering them available for absorption into the blood stream. Tryptic digestion is a necessary step in protein absorption as proteins are generally too large to be absorbed through the lining of the small intestine.


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Wikipedia

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