Neurokinin 1
| tachykinin receptor 1 | |
|---|---|
| Identifiers | |
| Symbol | TACR1 |
| Alt. symbols | TAC1R |
| Entrez | 6869 |
| HUGO | 11526 |
| OMIM | 162323 |
| RefSeq | NM_001058 |
| UniProt | P25103 |
| Other data | |
| Locus | Chr. 2 p13.1-p12 |
| tachykinin receptor 2 | |
|---|---|
| Identifiers | |
| Symbol | TACR2 |
| Alt. symbols | TAC2R, NKNAR |
| Entrez | 6865 |
| HUGO | 11527 |
| OMIM | 162321 |
| RefSeq | NM_001057 |
| UniProt | P21452 |
| Other data | |
| Locus | Chr. 10 q11-q21 |
| tachykinin receptor 3 | |
|---|---|
| Identifiers | |
| Symbol | TACR3 |
| Entrez | 6870 |
| HUGO | 11528 |
| OMIM | 162332 |
| RefSeq | NM_001059 |
| UniProt | P29371 |
| Other data | |
| Locus | Chr. 4 q25 |
There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
The genes and receptor ligands are as follows:
(Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
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