Tachykinin receptor 3

TACR3
Identifiers
Aliases	TACR3, HH11, NK-3R, NK3R, NKR, TAC3RL, Tachykinin receptor 3
External IDs	MGI: 892968 HomoloGene: 824 GeneCards: TACR3
Gene location (Human) Chr. Chromosome 4 (human) Band 4q24 Start 103,586,031 bp End 103,719,816 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 G3 Start 134,829,007 bp End 134,934,579 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • tachykinin receptor activity • G-protein coupled receptor activity • signal transducer activity • protein binding Cellular component • cytoplasm • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • dendrite membrane • neuronal cell body membrane • nucleus • sperm midpiece Biological process • response to estradiol • aging • hyperosmotic salinity response • regulation of feeding behavior • regulation of dopamine metabolic process • positive regulation of heart rate • response to morphine • positive regulation of blood pressure • signal transduction • positive regulation of uterine smooth muscle contraction • response to cocaine • tachykinin receptor signaling pathway • positive regulation of flagellated sperm motility • G-protein coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6870	21338
Ensembl	ENSG00000169836	ENSMUSG00000028172
UniProt	P29371	P47937
RefSeq (mRNA)	NM_001059	NM_021382
RefSeq (protein)	NP_001050	NP_067357
Location (UCSC)	Chr 4: 103.59 – 103.72 Mb	Chr 4: 134.83 – 134.93 Mb
PubMed search

6870

21338

ENSG00000169836

ENSMUSG00000028172

P29371

P47937

NM_001059

NM_021382

NP_001050

NP_067357

Tachykinin receptor 3, also known as TACR3, is a protein which in humans is encoded by the TACR3 gene.

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.

A number of selective ligands are available for NK₃. NK₃ receptor antagonists are being investigated as treatments for various indications.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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