Tachykinin receptor 1

TACR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KSB, 2KS9, 2KSA
Identifiers
Aliases	TACR1, NK1R, NKIR, SPR, TAC1R, tachykinin receptor 1
External IDs	OMIM: 162323 MGI: 98475 HomoloGene: 20288 GeneCards: TACR1
Targeted by Drug
eledoisin, Kassinin, physalaemin, substance p, aprepitant, ezlopitant, fosaprepitant, lanepitant, netupitant, osanetant, saredutant, vestipitant, vofopitant
Gene ontology Molecular function • tachykinin receptor activity • G-protein coupled receptor activity • signal transducer activity • protein binding • substance P receptor activity Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane • cell periphery • cytoplasm • cell surface • dendrite • cell body Biological process • G-protein coupled receptor signaling pathway • regulation of uterine smooth muscle contraction • tachykinin receptor signaling pathway • phospholipase C-activating G-protein coupled receptor signaling pathway • response to pain • detection of abiotic stimulus • inflammatory response • positive regulation of smooth muscle contraction • signal transduction • chemical synaptic transmission • aggressive behavior • acute inflammatory response • positive regulation of leukocyte migration • angiotensin-mediated drinking behavior • positive regulation of cytosolic calcium ion concentration • learning or memory • long-term memory • regulation of blood pressure • associative learning • response to heat • response to hormone • response to ozone • positive regulation of epithelial cell migration • response to auditory stimulus • response to organic cyclic compound • regulation of smooth muscle cell migration • sensory perception of pain • positive regulation of synaptic transmission, cholinergic • positive regulation of synaptic transmission, GABAergic • response to estradiol • response to progesterone • response to nicotine • operant conditioning • positive regulation of renal sodium excretion • sperm ejaculation • eating behavior • positive regulation of vascular permeability • response to morphine • response to ethanol • positive regulation of action potential • positive regulation of blood pressure • positive regulation of ossification • positive regulation of vasoconstriction • positive regulation of saliva secretion • positive regulation of hormone secretion • behavioral response to pain • regulation of smooth muscle cell proliferation • positive regulation of lymphocyte proliferation • positive regulation of epithelial cell proliferation • positive regulation of stress fiber assembly • response to electrical stimulus • smooth muscle contraction involved in micturition • positive regulation of uterine smooth muscle contraction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6869	21336
Ensembl	ENSG00000115353	ENSMUSG00000030043
UniProt	P25103	P30548
RefSeq (mRNA)	NM_015727 NM_001058	NM_009313
RefSeq (protein)	NP_001049 NP_056542	NP_033339.2 NP_033339
Location (UCSC)	Chr 2: 75.05 – 75.2 Mb	Chr 6: 82.4 – 82.56 Mb
PubMed search

2KSB, 2KS9, 2KSA

6869

21336

ENSG00000115353

ENSMUSG00000030043

P25103

P30548

NM_015727
NM_001058

NM_009313

NP_001049
NP_056542

NP_033339.2
NP_033339

The tachykinin receptor 1 (TACR1) also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR) is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene.

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