Tachykinin receptor 2

TACR2
Identifiers
Aliases	TACR2, NK2R, NKNAR, SKR, TAC2R, Tachykinin receptor 2
External IDs	MGI: 98477 HomoloGene: 55548 GeneCards: TACR2
Gene ontology Molecular function • tachykinin receptor activity • G-protein coupled receptor activity • substance K receptor activity • signal transducer activity • protein binding Cellular component • integral component of membrane • membrane • plasma membrane • integral component of plasma membrane Biological process • intestine smooth muscle contraction • positive regulation of acetylcholine secretion, neurotransmission • G-protein coupled receptor signaling pathway • excretion • muscle contraction • negative regulation of luteinizing hormone secretion • prolactin secretion • operant conditioning • response to electrical stimulus • regulation of uterine smooth muscle contraction • positive regulation of vascular permeability • positive regulation of ion transport • positive regulation of smooth muscle contraction • signal transduction • positive regulation of uterine smooth muscle contraction • tachykinin receptor signaling pathway • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6865	21337
Ensembl	ENSG00000075073	ENSMUSG00000020081
UniProt	P21452	P30549
RefSeq (mRNA)	NM_001057	NM_009314
RefSeq (protein)	NP_001048	NP_033340.3 NP_033340
Location (UCSC)	Chr 10: 69.4 – 69.42 Mb	Chr 10: 62.25 – 62.27 Mb
PubMed search

6865

21337

ENSG00000075073

ENSMUSG00000020081

P21452

P30549

NM_001057

NM_009314

NP_001048

NP_033340.3
NP_033340

Substance-K receptor is a protein that in humans is encoded by the TACR2 gene.

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.

Several selective ligands for NK₂ are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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