Monoamine oxidase A

MAOA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z5Y, 2BXR, 2BXS, 2Z5X
Identifiers
Aliases	MAOA, MAO-A, monoamine oxidase A
External IDs	OMIM: 309850 MGI: 96915 HomoloGene: 203 GeneCards: MAOA
Targeted by Drug
befloxatone, clorgiline, moclobemide, pirlindole, tranylcypromine, phenelzine
Gene ontology Molecular function • primary amine oxidase activity • oxidoreductase activity Cellular component • integral component of membrane • mitochondrial outer membrane • membrane • mitochondrion Biological process • oxidation-reduction process • catecholamine metabolic process • dopamine catabolic process • neurotransmitter catabolic process • cellular biogenic amine metabolic process • neurotransmitter metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4128	17161
Ensembl	ENSG00000189221	ENSMUSG00000025037
UniProt	P21397	Q64133
RefSeq (mRNA)	NM_001270458 NM_000240	NM_173740
RefSeq (protein)	NP_000231 NP_001257387	NP_776101.3 NP_776101
Location (UCSC)	Chr X: 43.65 – 43.75 Mb	Chr X: 16.62 – 16.69 Mb
PubMed search

2Z5Y, 2BXR, 2BXS, 2Z5X

4128

17161

ENSG00000189221

ENSMUSG00000025037

P21397

Q64133

NM_001270458
NM_000240

NM_173740

NP_000231
NP_001257387

NP_776101.3
NP_776101

Monoamine oxidase A, also known as MAO-A, is an enzyme that in humans is encoded by the MAOA gene. This gene is one of two neighboring gene family members that encode enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. A mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed.

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