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Methylparaben

Methylparaben
Methylparaben.svg
Methylparaben.png
Names
IUPAC name
Methyl 4-hydroxybenzoate
Other names
Methyl paraben;
Methyl p-hydroxybenzoate;
Methyl parahydroxybenzoate;
Nipagin M;
E number E218; Tegosept; Mycocten
Identifiers
99-76-3 YesY
3D model (Jmol) Interactive image
ChEBI CHEBI:31835 N
ChEMBL ChEMBL325372 YesY
ChemSpider 7176 YesY
ECHA InfoCard 100.002.532
E number E218 (preservatives)
6273
KEGG D01400 YesY
PubChem 7456
UNII A2I8C7HI9T YesY
Properties
C8H8O3
Molar mass 152.15 g·mol−1
Appearance Colorless crystals or white crystalline powder
UV-vis (λmax) 255 nm (methanol)
-88.7·10−6 cm3/mol
Hazards
NFPA 704
Flammability code 1: Must be pre-heated before ignition can occur. Flash point over 93 °C (200 °F). E.g., canola oil Health code 1: Exposure would cause irritation but only minor residual injury. E.g., turpentine Reactivity code 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g., liquid nitrogen Special hazards (white): no codeNFPA 704 four-colored diamond
Related compounds
Related Parabens
Ethylparaben
Propylparaben
Butylparaben
Related compounds
 Methyl salicylate (ortho isomer)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N  (what is YesYN ?)
Infobox references

Methylparaben, also methyl paraben, one of the parabens, is a preservative with the chemical formula CH3(C6H4(OH)COO). It is the methyl ester of p-hydroxybenzoic acid.

Methylparaben serves as a pheromone for a variety of insects and is a component of queen mandibular pheromone. Some plants produce methylparaben, example thale cress. It is commonly used in the preparation of liquid dosage forms.

Methylparaben is an anti-fungal agent often used in a variety of cosmetics and personal-care products. It is also used as a food preservative and has the E number E218.

Methylparaben is commonly used as a fungicide in Drosophila food media. To Drosophila, methylparaben is toxic at higher concentrations, has an estrogenic effect, and slows the growth rate in the larval and pupal stages at lower concentrations.

There is controversy about whether methylparaben or propylparabens are harmful at concentrations typically used in body care or cosmetics. Methylparaben and propylparaben are considered generally recognized as safe (GRAS) for food and cosmetic antibacterial preservation. Methylparaben is readily metabolized by common soil bacteria, making it completely biodegradable.

Methylparaben is readily absorbed from the gastrointestinal tract or through the skin. It is hydrolyzed to p-hydroxybenzoic acid and rapidly excreted in urine without accumulating in the body. Acute toxicity studies have shown that methylparaben is practically non-toxic by both oral and parenteral administration in animals. In a population with normal skin, methylparaben is practically non-irritating and non-sensitizing; however, allergic reactions to ingested parabens have been reported.


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