Queen mandibular pheromone

Queen mandibular pheromone, or QMP, is a honey bee pheromone produced by the queen and fed to her attendants who share it with the rest of the colony that gives the colony the sense of being queenright. Newly emerged queens produce very little QMP. By the sixth day they are producing enough to attract drones for mating. A laying queen makes twice that amount. Lack of QMP seems to attract robber bees. A study of foraging worker bees has suggested that foraging bees are not attracted to QMP.

Chemically, QMP is very diverse, with at least 17 major components and other minor ones. Five of these compounds are: 9-oxo-2-decenoic acid (9ODA), cis- and trans-9-hydroxydec-2-enoic acid (9HDA), methyl p-hydroxybenzoate (HOB) and 4-hydroxy-3-methoxyphenylethanol (HVA).

QMP functions as a sex pheromone for drones, attracting males to an unmated queen. 9ODA specifically is known to attract drones over long distances, and its combination with 9HDA and 10HDA at close range increases drone attraction to the queen.

Drone detection of 9ODA begins in the antennae, triggering a pathway that leads to behavioral responses. This begins with diffusion of 9ODA through the antennae's pores, into the lymph of the olfactory sensillum. The hydrophilic domain of carrier protein ASP1 binds to an apolar region of 9ODA, forming a complex that is transported to olfactory receptors located in the olfactory receptor neurons (ORNs). Olfactory receptor AmOR11 specifically is involved in responding to the pheromone/carrier complex. Although expressed in all castes, expression of AmOR11 is significantly higher in drones, further suggesting its role in 9ODA detection. The binding of the pheromone/carrier to AmOR11 sends a signal to the brain's primary olfactory centres. The specific neural pathway by which 9ODA causes behavioral changes is not yet developed in bees, however research shows olfactory signals from floral odors are integrated to the level of mushroom bodies. Research has not been conducted for the 9ODA pathway.

Components of QMP also function as a retinue pheromone, causing retinue behavioral and physiological changes in the female worker bees. Changes in QMP's chemical composition following a queen's mating attracts young worker bees to her, fulfilling her feeding and grooming requirements. QMP is transferred through contact from the queen to young workers, and in turn to the rest of the hive's workers. In doing so, the queen elicits behavioral changes in remaining workers, preventing the rearing of new queens, and preventing ovary development.

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