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Metabotropic glutamate receptor 8

GRM8
Identifiers
Aliases GRM8, GLUR8, GPRC1H, MGLUR8, mGlu8, glutamate metabotropic receptor 8
External IDs MGI: 1351345 HomoloGene: 654 GeneCards: GRM8
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000845
NM_001127323

NM_008174
NM_001311072

RefSeq (protein)

NP_000836
NP_001120795

NP_001298001
NP_032200

Location (UCSC) Chr 7: 126.44 – 127.25 Mb Chr 6: 27.28 – 28.14 Mb
PubMed search

NM_000845
NM_001127323

NM_008174
NM_001311072

NP_000836
NP_001120795

NP_001298001
NP_032200

Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.


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Wikipedia

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