GRM7

GRM7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3MQ4, 5C5C
Identifiers
Aliases	GRM7, GLUR7, GPRC1G, MGLU7, MGLUR7, PPP1R87, glutamate metabotropic receptor 7
External IDs	MGI: 1351344 HomoloGene: 20233 GeneCards: GRM7
Gene ontology Molecular function • glutamate receptor activity • calcium ion binding • PDZ domain binding • serine binding • G-protein coupled receptor activity • group III metabotropic glutamate receptor activity • adenylate cyclase inhibitor activity • signal transducer activity • glutamate binding • calcium channel regulator activity Cellular component • integral component of membrane • postsynaptic membrane • membrane • receptor complex • plasma membrane • integral component of plasma membrane • dendritic shaft • presynaptic active zone • axon • dendrite • cell cortex • asymmetric synapse • presynaptic membrane Biological process • G-protein coupled receptor signaling pathway • negative regulation of adenylate cyclase activity • negative regulation of glutamate secretion • response to stimulus • sensory perception of sound • behavioral fear response • sensory perception of smell • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • negative regulation of cAMP biosynthetic process • signal transduction • regulation of cyclase activity • regulation of synaptic transmission, glutamatergic • regulation of molecular function • chemical synaptic transmission Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2917	108073
Ensembl	ENSG00000196277	ENSMUSG00000056755
UniProt	Q14831	Q68ED2
RefSeq (mRNA)	NM_000844 NM_181874 NM_181875	NM_177328 NM_001346640
RefSeq (protein)	NP_000835 NP_870989	NP_001333569 NP_796302
Location (UCSC)	Chr 3: 6.77 – 7.74 Mb	Chr 6: 110.65 – 111.57 Mb
PubMed search

3MQ4, 5C5C

2917

108073

ENSG00000196277

ENSMUSG00000056755

Q14831

Q68ED2

NM_000844
NM_181874
NM_181875

NM_177328
NM_001346640

NP_000835
NP_870989

NP_001333569
NP_796302

Metabotropic glutamate receptor 7 is a protein that in humans is encoded by the GRM7 gene.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.

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Wikipedia