GRM6

GRM6
Identifiers
Aliases	GRM6, CSNB1B, GPRC1F, MGLUR6, mGlu6, glutamate metabotropic receptor 6
External IDs	MGI: 1351343 HomoloGene: 20232 GeneCards: GRM6
Gene ontology Molecular function • glutamate receptor activity • G-protein coupled receptor activity • protein homodimerization activity • signal transducer activity • adenylate cyclase inhibiting G-protein coupled glutamate receptor activity • protein binding Cellular component • integral component of membrane • Golgi apparatus • cell projection • endoplasmic reticulum membrane • membrane • Golgi membrane • plasma membrane • integral component of plasma membrane • dendrite • endoplasmic reticulum • presynaptic membrane • new growing cell tip Biological process • G-protein coupled glutamate receptor signaling pathway • G-protein coupled receptor signaling pathway • detection of visible light • locomotory behavior • response to stimulus • sensory perception of light stimulus • detection of light stimulus involved in visual perception • positive regulation of calcium ion import • retina development in camera-type eye • signal transduction • visual perception • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2916	108072
Ensembl	ENSG00000113262	ENSMUSG00000000617
UniProt	O15303	Q5NCH9
RefSeq (mRNA)	NM_000843	NM_173372
RefSeq (protein)	NP_000834	NP_775548
Location (UCSC)	Chr 5: 178.98 – 179 Mb	Chr 11: 50.85 – 50.87 Mb
PubMed search

2916

108072

ENSG00000113262

ENSMUSG00000000617

O15303

Q5NCH9

NM_000843

NM_173372

NP_000834

NP_775548

Glutamate receptor, metabotropic 6, also known as GRM6, is a protein which in humans is encoded by the GRM6 gene.

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.

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Wikipedia