Metabotropic glutamate receptor 4

GRM4

Identifiers

GRM4, GPRC1D, MGLUR4, mGlu4, glutamate metabotropic receptor 4

External IDs

MGI: 1351341 HomoloGene: 20230 GeneCards: GRM4

Gene ontology
Molecular function	• glutamate receptor activity • G-protein coupled receptor activity • signal transducer activity
Cellular component	• integral component of membrane • plasma membrane • integral component of plasma membrane • intracellular • presynaptic membrane • cytoplasmic vesicle • membrane
Biological process	• G-protein coupled receptor signaling pathway • regulation of neuron apoptotic process • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • activation of MAPK activity • neurotransmitter secretion • positive regulation of MAPK cascade • signal transduction • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


2914


268934

Ensembl


ENSG00000124493


ENSMUSG00000063239

UniProt


Q14833


Q68EF4

RefSeq (mRNA)

NM_000841 NM_001256809 NM_001256810 NM_001256811 NM_001256812
NM_001256813 NM_001256814 NM_001282847


NM_001013385 NM_001291045

RefSeq (protein)

NP_000832 NP_001243738 NP_001243740 NP_001243741 NP_001243742
NP_001269776


NP_001013403 NP_001277974

Location (UCSC)

Chr 6: 34.02 – 34.16 Mb

Chr 17: 27.42 – 27.51 Mb

PubMed search

NM_001256813
NM_001256814
NM_001282847

NM_001013385
NM_001291045

NP_001269776

NP_001013403
NP_001277974

Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene.

Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor family. Group III receptors are linked to the inhibition of the cyclic AMP cascade. Activation of GRM4 has potential therapeutic benefits in the treatment of parkinson's disease. Splice variant "taste-GRM4" is involved in the perception of umami taste.

...
Wikipedia