GRM4

GRM4
Identifiers
Aliases	GRM4, GPRC1D, MGLUR4, mGlu4, glutamate metabotropic receptor 4
External IDs	MGI: 1351341 HomoloGene: 20230 GeneCards: GRM4
Gene location (Human) Chr. Chromosome 6 (human) Band n/a Start 34,018,645 bp End 34,155,622 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band n/a Start 27,422,387 bp End 27,513,341 bp
RNA expression pattern More reference expression data
Gene ontology Molecular function • glutamate receptor activity • G-protein coupled receptor activity • signal transducer activity Cellular component • integral component of membrane • plasma • integral component of plasma membrane • intracellular • presynaptic membrane • cytoplasmic vesicle • membrane Biological process • G-protein coupled receptor signaling pathway • regulation of neuron apoptotic process • adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway • activation of MAPK activity • neurotransmitter secretion • positive regulation of MAPK cascade • signal transduction • chemical synaptic transmission • regulation of synaptic transmission, glutamatergic Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2914	268934
Ensembl	ENSG00000124493	ENSMUSG00000063239
UniProt	Q14833	Q68EF4
RefSeq (mRNA)	NM_000841 NM_001256809 NM_001256810 NM_001256811 NM_001256812 NM_001256813 NM_001256814 NM_001282847	NM_001013385 NM_001291045
RefSeq (protein)	NP_000832 NP_001243738 NP_001243740 NP_001243741 NP_001243742 NP_001269776	NP_001013403 NP_001277974
Location (UCSC)	Chr 6: 34.02 – 34.16 Mb	Chr 6: 27.42 – 27.51 Mb
PubMed search

2914

268934

ENSG00000124493

ENSMUSG00000063239

Q14833

Q68EF4

NM_001256813
NM_001256814
NM_001282847

NM_001013385
NM_001291045

NP_001269776

NP_001013403
NP_001277974

Metabotropic glutamate receptor 4 is a protein that in humans is encoded by the GRM4 gene.

Together with GRM6, GRM7 and GRM8 it belongs to group III of the metabotropic glutamate receptor family. Group III receptors are linked to the inhibition of the cyclic AMP cascade. Activation of GRM4 has potential therapeutic benefits in the treatment of parkinson's disease. Splice variant "taste-GRM4" is involved in the perception of umami taste.

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Wikipedia