MTA3

MTA3
Identifiers
Aliases	MTA3, metastasis associated 1 family member 3
External IDs	MGI: 2151172 HomoloGene: 14282 GeneCards: MTA3
Gene location (Human) Chr. Chromosome 2 (human) Band 2p21 Start 42,494,569 bp End 42,756,947 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 E4 Start 83,706,163 bp End 83,821,516 bp
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding • DNA binding • zinc ion binding • chromatin binding • protein binding • metal ion binding • histone deacetylase activity • RNA polymerase II transcription factor activity, sequence-specific DNA binding • macromolecular complex binding Cellular component • intracellular membrane-bounded organelle • cell nucleus • nucleoplasm • cytoplasm Biological process • negative regulation of transcription, DNA-templated • regulation of transcription, DNA-templated • histone deacetylation • positive regulation of cell proliferation • positive regulation of G2/M transition of mitotic cell cycle • regulation of transcription from RNA polymerase II promoter Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57504	116871
Ensembl	ENSG00000057935	ENSMUSG00000055817
UniProt	Q9BTC8	Q924K8
RefSeq (mRNA)	NM_001282755 NM_001282756 NM_020744 NM_001330442 NM_001330443 NM_001330444	NM_001171052 NM_001171053 NM_001171054 NM_054082
RefSeq (protein)	NP_001269684 NP_001269685 NP_001317371 NP_001317372 NP_001317373 NP_065795	NP_001164523 NP_001164524 NP_001164525 NP_473423
Location (UCSC)	Chr 2: 42.49 – 42.76 Mb	Chr 17: 83.71 – 83.82 Mb
PubMed search

57504

116871

ENSG00000057935

ENSMUSG00000055817

Q9BTC8

Q924K8

NM_001330444

NM_001171052
NM_001171053
NM_001171054
NM_054082

NP_065795

NP_001164523
NP_001164524
NP_001164525
NP_473423

Metastasis-associated protein MTA3 is a protein that in humans is encoded by the MTA3 gene. MTA3 protein localizes in the nucleus as well as in other cellular compartments MTA3 is a component of the nucleosome remodeling and deacetylate (NuRD) complex and participates in gene expression. The expression pattern of MTA3 is opposite to that of MTA1 and MTA2 during mammary gland tumorigenesis. However, MTA3 is also overexpressed in a variety of human cancers.

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